Skin health - Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

This clinical trial was aimed at evaluating the efficacy of Belmarama™ Rejuvenating Capsules, a unique encapsulated cosmetic serum, on facial skin characteristics.

The capsule design was chosen because it represents a unique, highly stable form of application that is resistant to degradation of ingredients with antioxidant properties, particularly in countries with hotter climates.

The trial was conducted by researcher and clinicians at the College of Integrative Medicine, Dhurakij Pundit University, and Siriraj Hospital, Mahidol University in Bangkok, Thailand, and the results were later published in the Journal of Cosmetic Dermatology in 2020.

A total of 50 Thai women (aged 30-65 yrs) were recruited to participate in the trial, for which they were allocated one capsule to be applied on one side of the face for 8 months, The other side of their face represented the untreated (control) side, and subjects maintaining their normally daily facial skin routine for both sides.

Dermatologists measured a range of skin parameters at baseline, weeks 4 and 8, including elasticity, elasticity, radiance, moisture, water evaporation, color and surface texture.

By 4 weeks, a significant difference was observed in skin gloss value, smoothness, scaliness and wrinkle density. By the 8-week mark, these differences were maintained, along with improvements in elasticity, melanin index (lighter pigment). There were no differences in moisture level, water loss or skin lifting around the eyes.

In summary, the present evaluation revealed improvements in skin integrity and pigmentation that indicated an anti-aging effect on Asian skin types. These effects are possibly related to the anti-oxidant actions of the serum ingredients.


Reference: Rattanawiwatpong et al. J Cosmet Dermatol. 2020 Mar;19(3):671-676


Full text available at:


Financial sponsor of study: Max Biocare Pty Ltd.